Initium-Pharm (Russia) has developed and proposed a new oral product: Vitaterpene CardioOrganic® Omega-3, based on Abisil terpenoid substance. It is a dietary supplement containing Siberian fir terpenes in a form of 5% oily solution in capsules for oral administration. It also contains phytogenic PUFAs and α-tocopherol. The product has a new range of pharmacological effects and provides new opportunities for managing pathogenic processes, particularly, atherosclerosis and metabolic syndrome.
Vitaterpene CardioOrganic® Omega-3 is a balanced complex of bioactive substances comprising natural Pinaceae family terpenes, limonene, polyunsaturated fatty acids (PUFAs), and α-tocopherol (vitamin E). It is recommended to use in the field of preventive medicine as an anti-atherosclerotic agent for cardiovascular diseases prophylaxis and treatment. The product helps to reduce risk of cardiovascular disease development and to manage carbohydrate and lipid metabolism disorders in cases of metabolic syndrome. It decreases blood levels of total lipids, cholesterol and glucose. Experimental studies demonstrated that administration of the balanced complex containing terpenes and phytogenic PUFAs produces anti-atherosclerotic effect, decreases level of triglycerides and low density lipoproteins (LDL), has choleretic effect, stimulates bile excretion of cholesterol and bile acids, decreases severity of aortic intima lesions and atherocalcinosis thereof, and prevents myocardial infraction development. In case of metabolic syndrome, it reduces blood pressure, blood levels of glucose and triglycerides, and the lithogenicity of bile.
CardioOrganic® Omega-3 can be used for a combined therapy of such conditions as peripheral arterial disease, hypertension, ischemic heart disease, type 2 diabetes mellitus, cerebrovascular diseases, atherosclerosis-related diseases, and other conditions.
Dietary supplement Vitaterpen of CardioOrganic® Omega-3 is an additional source of Omega-3 Polyunsaturated Fatty Acids (PUFA), limonene, vitamin E. It contains Siberian fir terpenes and essential oils.
Flax-seed oil, Siberian fir terpenes, vitamin E; coating components: gelatin, glycerin (E422, water-retaining agent), water, potassium sorbate (E202, preservation agent), citric acid (E330, antioxidant).
Content in a daily dose
(3 capsules), not less than, mg
% RDA1/ %AI 2
|Omega-3 PUFA (α-alpha-linolenic), mg||
|Vitamin Е, mg||
% RDA1 – per cent of Recommended Dietary Allowance according to Technical Regulation of Customs Union 022/2011 “Labeling of Food Products”, Annex 2
% AI2 – per cent of an adequate intake in accordance with the Unified Sanitary, Epidemiological, and Hygienic Requirements for Goods Subject to Sanitary and Epidemiological Supervision (Control), Annex 5
* – does not exceed the tolerable upper intake level
Nutritional value of 1 capsule: Proteins – 0.15 g; Fats – 0.55 g
Energy, kcal/kJ / 1 capsule – 5.55 / 22.9
Pharmaceutical form and presentation
Soft gelatin capsules, 600 mg
Description of properties of the capsule components
Terpenes are a wonderful group of secondary metabolites of higher plants that have no analogues in terms of the diversity of structural types and biological roles in the regulation of life processes of living organisms. Numbering more than 23 thousand compounds with an established chemical structure, this numerous group of substances outnumbers all other classes of natural compounds. These compounds are represented by mono-, sesqui-, di- and triterpenoids. In addition, according to literature sources, a number of terpenoids are the starting or intermediate components in the biosynthesis of such biologically active substances as steroid hormones, enzymes, antioxidants, vitamins A, D, E, K1, 3, 4.
Experimentally validated effects of Siberian fir terpenes 2
1. They reduce the level of:
– total lipids
– total cholesterol
– Atherogenic Index
– Lecithin-cholesterol index
2. Antiatherogenic effect:
– prevent the area of the aortic intima lesion
– prevent atherocalcinosis
– prevent myocardial infarction
3. They reduce blood pressure
4. They reduce glucose levels in 30 and 60 minutes in case of carbohydrate loading
5. Choleretic effect:
– increase in the amount of bile and a cholate-cholesterol index
6. Anti-inflammatory effect:
– suppress the infiltration of leukocytes, neutrophils, lymphocytes, monocytes/macrophages in the site of inflammation
Limonene is a hydrocarbon derivative of the group of monocyclic terpenes. It is contained in essential oils of coniferous trees. It has a pronounced pine smell.
Flax-seed oil contains vegetable Omega-3 PUFA, including α-linoleic acid, which plays an important role in metabolic processes. It helps to regulate fat and protein metabolism, to prevent the accumulation of cholesterol in the blood vessels and the formation of blood clots.
Omega-3 is a group of Polyunsaturated Fatty Acids (PUFA), which helps to protect cell membranes from destruction. Without these compounds, it is impossible to assure the proper functioning of nervous, immune and cardiovascular systems, adequate synthesis of tissue hormones, prostaglandins, and a good metabolism of essential substances. In addition, they suppress inflammatory processes, improve the joints health, and fight emotional disorders and chronic fatigue syndrome.
Alpha-linolenic acid (ALA) helps to fight stress, bad cholesterol, high blood pressure, as well as skin, hair and nail problems (dryness, seborrhea, and peeling). In addition, it is a building substrate for the synthesis of eicosapentaenoic EPA and docosahexaenoic DHA fatty acids.
Vitamin E (alpha tocopherol) is a fat-soluble biologically active substance which has powerful antioxidant and radioprotective properties.
Specialists recommend using Vitaterpen of CardioOrganic® Omega-3 as a means of preventing the risk of cardiovascular disorders, as well as a part of the complex therapy in the treatment of atherosclerosis of peripheral vessels, hypertension, and ischemic heart disease. As for endocrine pathologies, specialists recommend using it as a means of correcting disorders of carbohydrate and lipid metabolism in the presence of metabolic syndrome, as well as in complex therapy in the treatment of type 2 diabetes mellitus2,5.
Recommendations for use : adult dosing is 1 capsule 3 times a day 20 minutes before meals.
Duration of administration is 1-2 months. If necessary, the course can be repeated. It is recommended to consult a physician before application.
Contraindications : individual intolerance to the components of the product, pregnancy, breast-feeding.
Storage . Store in a dry place, protected from direct sunlight and out of the reach of children, at a temperature not exceeding 25 °C. During storage, the contents of the capsules may be subject to peeling due to their composition, which won’t affect the quality of the product.
Shelf-life : 2 years from the date of manufacture.
Specialists recommend using Dietary supplement Vitaterpen of CardioOrganic® Omega-3 as a means of preventing the risk of cardiovascular disorders, as well as a part of the complex therapy in the treatment of atherosclerosis of peripheral vessels, hypertension, and ischemic heart disease. As for endocrine pathologies, specialists recommend using it as a means of correcting disorders of carbohydrate and lipid metabolism in the presence of metabolic syndrome, as well as in complex therapy in the treatment of type 2 diabetes mellitus2,5.
* Preventive and Restorative Medicine
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